The kidneys filter waste and extra water out of the blood and are important in controlling blood pressure and other essential body functions. When kidneys are not functioning properly, waste builds up in the body and can cause serious health problems. Deutsche Bank Securities Inc. is acting for Warner Chilcott as financial advisor and is not acting as financial advisor to anyone else in connection with the matters referred to in this announcement and will not be responsible to anyone other than Warner Chilcott in connection therewith for providing advice in relation to the matters referred to in this announcement. Deutsche Bank Securities Inc. has delegated certain of its financial advisory functions and responsibilities to Deutsche Bank AG, acting through its London branch. Deutsche Bank AG, acting through its London branch is performing such delegated functions and responsibilities exclusively for Warner Chilcott and is not acting as a financial adviser for any other person in connection with the matters referred to in this announcement and will not be responsible to any such other person for providing advice in relation to the matters referred to in this announcement. Deutsche Bank AG is authorised under German Banking Law (competent authority: BaFin ? Federal Financial Supervisory Authority) and authorised and subject to limited regulation by the Financial Conduct Authority. Details about the extent of Deutsche Bank AG's authorization and regulation by the Financial Conduct Authority are available on request. The report addresses specific clinical, design, and operational considerations for pediatric diabetes clinical trials. These factors include rational study design based on an understanding of developmental physiology, emotional development, and the particular clinical and pathologic manifestations of diabetes. The report concludes that the disease burden is high, with a large unmet need for new diabetes therapies in the pediatric population, and provides information to assist in the planning of pediatric studies aimed at making more treatment options available to children.

In the second study, the researchers staged an introductory conversation involving 77 college students who thought they were involved in a study on first impressions. Half of the students were excluded in an online chat room. The others were ignored in person by research assistants posing as fellow study participants. Serious and/or life-threatening peripheral ischemia has been associated with the coadministration of dihydroergotamine with potent CYP3A4 inhibitors including protease inhibitors and macrolide antibiotics. Because CYP3A4 inhibition elevates the serum levels of dihydroergotamine, the risk for vasospasm leading to cerebral ischemia and/or ischemia of the extremities is increased. Hence, concomitant use of these medications is contraindicated. MONDAY March 2, 2015, 2015 -- Drinking three to five cups of coffee a day may reduce the risk of developing clogged arteries, which in turn might reduce the risk for heart attack, a new study suggests. Besides winning Agency of the Year (Category III), McCann Echo Torre Lazur (METL) added a substantial amount of new business, contributing to double-digit growth. METL was chosen by Teva Pharmaceutical to launch a new indication for Nuvigil. Other sizeable wins include the Rebif business and the addition of NovoLog Mix 70/30 and the global assignment for NovoRapid to its Novo Nordisk portfolio. Galderma Laboratories LP and METL continue their long-standing partnership on the acne and rosacea franchises, and METL was awarded another U.S. and global launch for ivermectin.

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